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KMID : 1021220160070020999
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국제물리치료학회지
2016 Volume.7 No. 2 p.999 ~ p.1005
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Effect of Low-Intensity Cardiac Rehabilitation on Cardiac Function and Degree of Fibrosis in a White Rat Acute Myocardial Infarction Model
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Ji Sung-Ha
Kim Ki-Jong
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Abstract
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The purpose of this study was to investigate the effects of low-intensity cardiac rehabilitation exercise on the cardiac function and the degree of fibrosis in an older white rat model. This study used male Sprague- Dawley white rats that were 50 weeks old. After the acute myocardial infarction induction, Twenty of the rats were randomly allocated into an experimental group and a control group, and each of the groups consisted of 8 rats. In the experimental group, the exercise was conducted for six weeks, 30 minutes a day, five days a week, using a Rotarod treadmill for animals. The degree of myocardial fibrosis was significantly repressed in the experimental group(13.69±1.90%) and in the control group(15.67±1.54%)(p<0.05). However, fractional shortening and ejection fraction did not show a significant difference. The results of this study suggest that cardiac rehabilitation with low intensity treadmill exercise repress the myocardial fibrosis.
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KEYWORD
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Cardiac Rehabilitation, Myocardial Infarction, Rat, Cardiac Function, Fibrosis
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